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Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety.
Basso AM, Bratcher NA, Gallagher KB, Cowart MD, Zhao C, Sun M, Esbenshade TA, Brune ME, Fox GB, Schmidt M, Collins CA, Souers AJ, Iyengar R, Vasudevan A, Kym PR, Hancock AA, Rueter LE. Basso AM, et al. Among authors: cowart md. Eur J Pharmacol. 2006 Jul 1;540(1-3):115-20. doi: 10.1016/j.ejphar.2006.04.043. Epub 2006 May 6. Eur J Pharmacol. 2006. PMID: 16765941
Selective H3 receptor (H3R) blockade: broad efficacy in cognition and schizophrenia.
Fox GB, Esbenshade TA, Pan JB, Browman KE, Zhang M, Ballard ME, Radek RJ, Miner H, Bitner RS, Krueger KM, Yao BB, Faghih R, Rueter LE, Komater VA, Drescher KU, Buckley MJ, Sullivan JP, Cowart MD, Decker MW, Hancock AA. Fox GB, et al. Among authors: cowart md. Inflamm Res. 2005 Apr;54 Suppl 1:S23-4. doi: 10.1007/s00011-004-0410-1. Inflamm Res. 2005. PMID: 15928819 No abstract available.
Antiobesity evaluation of histamine H3 receptor (H3R) antagonist analogs of A-331440 with improved safety and efficacy.
Hancock AA, Diehl MS, Fey TA, Bush EN, Faghih R, Miller TR, Krueger KM, Pratt JK, Cowart MD, Dickinson RW, Shapiro R, Knourek-Segel VE, Droz BA, McDowell CA, Krishna G, Brune ME, Esbenshade TA, Jacobson PB. Hancock AA, et al. Among authors: cowart md. Inflamm Res. 2005 Apr;54 Suppl 1:S27-9. doi: 10.1007/s00011-004-0412-z. Inflamm Res. 2005. PMID: 15928821 No abstract available.
Distinctions and contradistinctions between antiobesity histamine H(3) receptor (H (3)R) antagonists compared to cognition-enhancing H (3) receptor antagonists.
Hancock AA, Bitner RS, Krueger KM, Otte S, Nikkel AL, Fey TA, Bush EN, Dickinson RW, Shapiro R, Knourek-Segel V, Droz BA, Brune ME, Jacobson PB, Cowart MD, Esbenshade TA. Hancock AA, et al. Among authors: cowart md. Inflamm Res. 2006 Apr;55 Suppl 1:S42-4. doi: 10.1007/s00011-005-0034-0. Inflamm Res. 2006. PMID: 16547814 No abstract available.
In vitro optimization of structure activity relationships of analogues of A-331440 combining radioligand receptor binding assays and micronucleus assays of potential antiobesity histamine H3 receptor antagonists.
Hancock AA, Diehl MS, Faghih R, Bush EN, Krueger KM, Krishna G, Miller TR, Wilcox DM, Nguyen P, Pratt JK, Cowart MD, Esbenshade TA, Jacobson PB. Hancock AA, et al. Among authors: cowart md. Basic Clin Pharmacol Toxicol. 2004 Sep;95(3):144-52. doi: 10.1111/j.1742-7843.2004.950307.x. Basic Clin Pharmacol Toxicol. 2004. PMID: 15447739 Free article.
Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist.
Fox GB, Esbenshade TA, Pan JB, Radek RJ, Krueger KM, Yao BB, Browman KE, Buckley MJ, Ballard ME, Komater VA, Miner H, Zhang M, Faghih R, Rueter LE, Bitner RS, Drescher KU, Wetter J, Marsh K, Lemaire M, Porsolt RD, Bennani YL, Sullivan JP, Cowart MD, Decker MW, Hancock AA. Fox GB, et al. Among authors: cowart md. J Pharmacol Exp Ther. 2005 Apr;313(1):176-90. doi: 10.1124/jpet.104.078402. Epub 2004 Dec 17. J Pharmacol Exp Ther. 2005. PMID: 15608077
Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: I. Potent and selective histamine H3 receptor antagonist with drug-like properties.
Esbenshade TA, Fox GB, Krueger KM, Miller TR, Kang CH, Denny LI, Witte DG, Yao BB, Pan L, Wetter J, Marsh K, Bennani YL, Cowart MD, Sullivan JP, Hancock AA. Esbenshade TA, et al. Among authors: cowart md. J Pharmacol Exp Ther. 2005 Apr;313(1):165-75. doi: 10.1124/jpet.104.078303. Epub 2004 Dec 17. J Pharmacol Exp Ther. 2005. PMID: 15608078
78 results