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Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.
Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, Lytton-Jean AK, Siegwart DJ, Akinc A, Barnes C, Barros SA, Carioto M, Fitzgerald K, Hettinger J, Kumar V, Novobrantseva TI, Qin J, Querbes W, Koteliansky V, Langer R, Anderson DG. Dong Y, et al. Among authors: chen d, chen y. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):3955-60. doi: 10.1073/pnas.1322937111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516150 Free PMC article.
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling.
Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG. Sahay G, et al. Among authors: chen d. Nat Biotechnol. 2013 Jul;31(7):653-8. doi: 10.1038/nbt.2614. Epub 2013 Jun 23. Nat Biotechnol. 2013. PMID: 23792629 Free PMC article.
Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery.
Zhang Y, Pelet JM, Heller DA, Dong Y, Chen D, Gu Z, Joseph BJ, Wallas J, Anderson DG. Zhang Y, et al. Among authors: chen d. Adv Mater. 2013 Sep 6;25(33):4641-5. doi: 10.1002/adma.201301917. Epub 2013 Jun 27. Adv Mater. 2013. PMID: 23813808 Free PMC article.
Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo.
Dong Y, Eltoukhy AA, Alabi CA, Khan OF, Veiseh O, Dorkin JR, Sirirungruang S, Yin H, Tang BC, Pelet JM, Chen D, Gu Z, Xue Y, Langer R, Anderson DG. Dong Y, et al. Among authors: chen d. Adv Healthc Mater. 2014 Sep;3(9):1392-7. doi: 10.1002/adhm.201400054. Epub 2014 Mar 13. Adv Healthc Mater. 2014. PMID: 24623658 Free PMC article.
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity.
Whitehead KA, Dorkin JR, Vegas AJ, Chang PH, Veiseh O, Matthews J, Fenton OS, Zhang Y, Olejnik KT, Yesilyurt V, Chen D, Barros S, Klebanov B, Novobrantseva T, Langer R, Anderson DG. Whitehead KA, et al. Among authors: chen d. Nat Commun. 2014 Jun 27;5:4277. doi: 10.1038/ncomms5277. Nat Commun. 2014. PMID: 24969323 Free PMC article.
Core-shell hydrogel microcapsules for improved islets encapsulation.
Ma M, Chiu A, Sahay G, Doloff JC, Dholakia N, Thakrar R, Cohen J, Vegas A, Chen D, Bratlie KM, Dang T, York RL, Hollister-Lock J, Weir GC, Anderson DG. Ma M, et al. Among authors: chen d. Adv Healthc Mater. 2013 May;2(5):667-72. doi: 10.1002/adhm.201200341. Epub 2012 Dec 3. Adv Healthc Mater. 2013. PMID: 23208618 Free PMC article.
Functionalized lipid-like nanoparticles for in vivo mRNA delivery and base editing.
Zhang X, Zhao W, Nguyen GN, Zhang C, Zeng C, Yan J, Du S, Hou X, Li W, Jiang J, Deng B, McComb DW, Dorkin R, Shah A, Barrera L, Gregoire F, Singh M, Chen D, Sabatino DE, Dong Y. Zhang X, et al. Among authors: chen d. Sci Adv. 2020 Aug 21;6(34):eabc2315. doi: 10.1126/sciadv.abc2315. Print 2020 Aug. Sci Adv. 2020. PMID: 32937374 Free PMC article.
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