Letai A - Search Results

1

Cell and molecular determinants of in vivo efficacy of the BH3 mimetic ABT-263 against pediatric acute lymphoblastic leukemia xenografts.

Suryani S, Carol H, Chonghaile TN, Frismantas V, Sarmah C, High L, Bornhauser B, Cowley MJ, Szymanska B, Evans K, Boehm I, Tonna E, Jones L, Manesh DM, Kurmasheva RT, Billups C, Kaplan W, Letai A, Bourquin JP, Houghton PJ, Smith MA, Lock RB. Suryani S, et al. Among authors: letai a. Clin Cancer Res. 2014 Sep 1;20(17):4520-31. doi: 10.1158/1078-0432.CCR-14-0259. Epub 2014 Jul 10. Clin Cancer Res. 2014. PMID: 25013123 Free PMC article.

2

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.

Certo M, Del Gaizo Moore V, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A. Certo M, et al. Among authors: letai a. Cancer Cell. 2006 May;9(5):351-65. doi: 10.1016/j.ccr.2006.03.027. Cancer Cell. 2006. PMID: 16697956 Free article.

3

Restoring cancer's death sentence.

Letai A. Letai A. Cancer Cell. 2006 Nov;10(5):343-5. doi: 10.1016/j.ccr.2006.10.014. Cancer Cell. 2006. PMID: 17097553 Free article.

4

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

Del Gaizo Moore V, Brown JR, Certo M, Love TM, Novina CD, Letai A. Del Gaizo Moore V, et al. Among authors: letai a. J Clin Invest. 2007 Jan;117(1):112-21. doi: 10.1172/JCI28281. J Clin Invest. 2007. PMID: 17200714 Free PMC article.

5

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents.

Deng J, Carlson N, Takeyama K, Dal Cin P, Shipp M, Letai A. Deng J, et al. Among authors: letai a. Cancer Cell. 2007 Aug;12(2):171-85. doi: 10.1016/j.ccr.2007.07.001. Cancer Cell. 2007. PMID: 17692808 Free article.

6

BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong SA, Letai A. Del Gaizo Moore V, et al. Among authors: letai a. Blood. 2008 Feb 15;111(4):2300-9. doi: 10.1182/blood-2007-06-098012. Epub 2007 Dec 4. Blood. 2008. PMID: 18056841 Free PMC article.

7

Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion.

Deng J, Shimamura T, Perera S, Carlson NE, Cai D, Shapiro GI, Wong KK, Letai A. Deng J, et al. Among authors: letai a. Cancer Res. 2007 Dec 15;67(24):11867-75. doi: 10.1158/0008-5472.CAN-07-1961. Cancer Res. 2007. PMID: 18089817

8

Alteration of the mitochondrial apoptotic pathway is key to acquired paclitaxel resistance and can be reversed by ABT-737.

Kutuk O, Letai A. Kutuk O, et al. Among authors: letai a. Cancer Res. 2008 Oct 1;68(19):7985-94. doi: 10.1158/0008-5472.CAN-08-1418. Cancer Res. 2008. PMID: 18829556 Free PMC article.

9

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.

Yecies D, Carlson NE, Deng J, Letai A. Yecies D, et al. Among authors: letai a. Blood. 2010 Apr 22;115(16):3304-13. doi: 10.1182/blood-2009-07-233304. Epub 2010 Mar 2. Blood. 2010. PMID: 20197552 Free PMC article.

10

Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.

Ni Chonghaile T, Sarosiek KA, Vo TT, Ryan JA, Tammareddi A, Moore Vdel G, Deng J, Anderson KC, Richardson P, Tai YT, Mitsiades CS, Matulonis UA, Drapkin R, Stone R, Deangelo DJ, McConkey DJ, Sallan SE, Silverman L, Hirsch MS, Carrasco DR, Letai A. Ni Chonghaile T, et al. Among authors: letai a. Science. 2011 Nov 25;334(6059):1129-33. doi: 10.1126/science.1206727. Epub 2011 Oct 27. Science. 2011. PMID: 22033517 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

211 results

Search Page