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The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription.
Okoye AA, Fromentin R, Takata H, Brehm JH, Fukazawa Y, Randall B, Pardons M, Tai V, Tang J, Smedley J, Axthelm M, Lifson JD, Picker LJ, Favre D, Trautmann L, Chomont N. Okoye AA, et al. Among authors: trautmann l. PLoS Pathog. 2022 Jan 18;18(1):e1010245. doi: 10.1371/journal.ppat.1010245. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35041707 Free PMC article.
Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection.
van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y, Gimmig S, Boucher G, Wilkinson P, Shi Y, Yassine-Diab B, Said EA, Trautmann L, El Far M, Balderas RS, Boulassel MR, Routy JP, Haddad EK, Sekaly RP. van Grevenynghe J, et al. Among authors: trautmann l. Nat Med. 2008 Mar;14(3):266-74. doi: 10.1038/nm1728. Epub 2008 Mar 2. Nat Med. 2008. PMID: 18311149
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation.
Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, Boucher G, Boulassel MR, Ghattas G, Brenchley JM, Schacker TW, Hill BJ, Douek DC, Routy JP, Haddad EK, Sékaly RP. Chomont N, et al. Among authors: trautmann l. Nat Med. 2009 Aug;15(8):893-900. doi: 10.1038/nm.1972. Epub 2009 Jun 21. Nat Med. 2009. PMID: 19543283 Free PMC article. Clinical Trial.
80 results