Kennedy ME - Search Results

1

Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment.

Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA. Funk CD, et al. Among authors: kennedy me. FASEB J. 1991 Jun;5(9):2304-12. FASEB J. 1991. PMID: 1907252

2

Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling.

Kennedy ME, Limbird LE. Kennedy ME, et al. J Biol Chem. 1993 Apr 15;268(11):8003-11. J Biol Chem. 1993. PMID: 8385131 Free article.

3

Unique structural features important for stabilization versus polarization of the alpha 2A-adrenergic receptor on the basolateral membrane of Madin-Darby canine kidney cells.

Keefer JR, Kennedy ME, Limbird LE. Keefer JR, et al. Among authors: kennedy me. J Biol Chem. 1994 Jun 10;269(23):16425-32. J Biol Chem. 1994. PMID: 8206950 Free article.

4

Palmitoylation of the alpha 2A-adrenergic receptor. Analysis of the sequence requirements for and the dynamic properties of alpha 2A-adrenergic receptor palmitoylation.

Kennedy ME, Limbird LE. Kennedy ME, et al. J Biol Chem. 1994 Dec 16;269(50):31915-22. J Biol Chem. 1994. PMID: 7989367 Free article.

5

Impaired Autophagic Clearance with a Gain-of-Function Variant of the Lysosomal Cl^-/H⁺ Exchanger ClC-7.

Bose S, de Heus C, Kennedy ME, Wang F, Jentsch TJ, Klumperman J, Stauber T. Bose S, et al. Among authors: kennedy me. Biomolecules. 2023 Dec 15;13(12):1799. doi: 10.3390/biom13121799. Biomolecules. 2023. PMID: 38136669 Free PMC article.

6

Microglial roles in Alzheimer's disease: An agent-based model to elucidate microglial spatiotemporal response to beta-amyloid.

Weathered C, Bardehle S, Yoon C, Kumar N, Leyns CEG, Kennedy ME, Bloomingdale P, Pienaar E. Weathered C, et al. Among authors: kennedy me. CPT Pharmacometrics Syst Pharmacol. 2024 Mar;13(3):449-463. doi: 10.1002/psp4.13095. Epub 2024 Feb 1. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 38078626 Free PMC article.

7

Discovery of MK-1468: A Potent, Kinome-Selective, Brain-Penetrant Amidoisoquinoline LRRK2 Inhibitor for the Potential Treatment of Parkinson's Disease.

Kattar SD, Gulati A, Margrey KA, Keylor MH, Ardolino M, Yan X, Johnson R, Palte RL, McMinn SE, Nogle L, Su J, Xiao D, Piesvaux J, Lee S, Hegde LG, Woodhouse JD, Faltus R, Moy LY, Xiong T, Ciaccio PJ, Pearson K, Patel M, Otte KM, Leyns CEG, Kennedy ME, Bennett DJ, DiMauro EF, Fell MJ, Fuller PH. Kattar SD, et al. Among authors: kennedy me. J Med Chem. 2023 Nov 9;66(21):14912-14927. doi: 10.1021/acs.jmedchem.3c01486. Epub 2023 Oct 20. J Med Chem. 2023. PMID: 37861679

8

Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease.

Leyns CEG, Prigent A, Beezhold B, Yao L, Hatcher NG, Tao P, Kang J, Suh E, Van Deerlin VM, Trojanowski JQ, Lee VMY, Kennedy ME, Fell MJ, Henderson MX. Leyns CEG, et al. Among authors: kennedy me. NPJ Parkinsons Dis. 2023 May 11;9(1):74. doi: 10.1038/s41531-023-00517-w. NPJ Parkinsons Dis. 2023. PMID: 37169750 Free PMC article.

9

The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130.

Müller SA, Shmueli MD, Feng X, Tüshaus J, Schumacher N, Clark R, Smith BE, Chi A, Rose-John S, Kennedy ME, Lichtenthaler SF. Müller SA, et al. Among authors: kennedy me. Mol Neurodegener. 2023 Feb 21;18(1):13. doi: 10.1186/s13024-023-00596-6. Mol Neurodegener. 2023. PMID: 36810097 Free PMC article.

10

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.

Candito DA, Simov V, Gulati A, Kattar S, Chau RW, Lapointe BT, Methot JL, DeMong DE, Graham TH, Kurukulasuriya R, Keylor MH, Tong L, Morriello GJ, Acton JJ, Pio B, Liu W, Scott JD, Ardolino MJ, Martinot TA, Maddess ML, Yan X, Gunaydin H, Palte RL, McMinn SE, Nogle L, Yu H, Minnihan EC, Lesburg CA, Liu P, Su J, Hegde LG, Moy LY, Woodhouse JD, Faltus R, Xiong T, Ciaccio P, Piesvaux JA, Otte KM, Kennedy ME, Bennett DJ, DiMauro EF, Fell MJ, Neelamkavil S, Wood HB, Fuller PH, Ellis JM. Candito DA, et al. Among authors: kennedy me. J Med Chem. 2022 Dec 22;65(24):16801-16817. doi: 10.1021/acs.jmedchem.2c01605. Epub 2022 Dec 7. J Med Chem. 2022. PMID: 36475697

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