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Transporter-mediated protection against thiopurine-induced hematopoietic toxicity.
Krishnamurthy P, Schwab M, Takenaka K, Nachagari D, Morgan J, Leslie M, Du W, Boyd K, Cheok M, Nakauchi H, Marzolini C, Kim RB, Poonkuzhali B, Schuetz E, Evans W, Relling M, Schuetz JD. Krishnamurthy P, et al. Among authors: schwab m. Cancer Res. 2008 Jul 1;68(13):4983-9. doi: 10.1158/0008-5472.CAN-07-6790. Cancer Res. 2008. PMID: 18593894 Free PMC article.
Nomenclature for alleles of the thiopurine methyltransferase gene.
Appell ML, Berg J, Duley J, Evans WE, Kennedy MA, Lennard L, Marinaki T, McLeod HL, Relling MV, Schaeffeler E, Schwab M, Weinshilboum R, Yeoh AE, McDonagh EM, Hebert JM, Klein TE, Coulthard SA. Appell ML, et al. Among authors: schwab m. Pharmacogenet Genomics. 2013 Apr;23(4):242-8. doi: 10.1097/FPC.0b013e32835f1cc0. Pharmacogenet Genomics. 2013. PMID: 23407052 Free PMC article.
Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process.
Caudle KE, Klein TE, Hoffman JM, Muller DJ, Whirl-Carrillo M, Gong L, McDonagh EM, Sangkuhl K, Thorn CF, Schwab M, Agundez JA, Freimuth RR, Huser V, Lee MT, Iwuchukwu OF, Crews KR, Scott SA, Wadelius M, Swen JJ, Tyndale RF, Stein CM, Roden D, Relling MV, Williams MS, Johnson SG. Caudle KE, et al. Among authors: schwab m. Curr Drug Metab. 2014 Feb;15(2):209-17. doi: 10.2174/1389200215666140130124910. Curr Drug Metab. 2014. PMID: 24479687 Free PMC article.
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.
Moriyama T, Nishii R, Perez-Andreu V, Yang W, Klussmann FA, Zhao X, Lin TN, Hoshitsuki K, Nersting J, Kihira K, Hofmann U, Komada Y, Kato M, McCorkle R, Li L, Koh K, Najera CR, Kham SK, Isobe T, Chen Z, Chiew EK, Bhojwani D, Jeffries C, Lu Y, Schwab M, Inaba H, Pui CH, Relling MV, Manabe A, Hori H, Schmiegelow K, Yeoh AE, Evans WE, Yang JJ. Moriyama T, et al. Among authors: schwab m. Nat Genet. 2016 Apr;48(4):367-73. doi: 10.1038/ng.3508. Epub 2016 Feb 15. Nat Genet. 2016. PMID: 26878724 Free PMC article.
OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.
Drenberg CD, Gibson AA, Pounds SB, Shi L, Rhinehart DP, Li L, Hu S, Du G, Nies AT, Schwab M, Pabla N, Blum W, Gruber TA, Baker SD, Sparreboom A. Drenberg CD, et al. Among authors: schwab m. Cancer Res. 2017 Apr 15;77(8):2102-2111. doi: 10.1158/0008-5472.CAN-16-2548. Epub 2017 Feb 16. Cancer Res. 2017. PMID: 28209616 Free PMC article.
Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update.
Relling MV, Schwab M, Whirl-Carrillo M, Suarez-Kurtz G, Pui CH, Stein CM, Moyer AM, Evans WE, Klein TE, Antillon-Klussmann FG, Caudle KE, Kato M, Yeoh AEJ, Schmiegelow K, Yang JJ. Relling MV, et al. Among authors: schwab m. Clin Pharmacol Ther. 2019 May;105(5):1095-1105. doi: 10.1002/cpt.1304. Epub 2019 Jan 20. Clin Pharmacol Ther. 2019. PMID: 30447069 Free PMC article.
Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities.
Chenoweth MJ, Giacomini KM, Pirmohamed M, Hill SL, van Schaik RHN, Schwab M, Shuldiner AR, Relling MV, Tyndale RF. Chenoweth MJ, et al. Among authors: schwab m. Clin Pharmacol Ther. 2020 Jan;107(1):57-61. doi: 10.1002/cpt.1664. Epub 2019 Nov 6. Clin Pharmacol Ther. 2020. PMID: 31696505 Free PMC article. No abstract available.
Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase.
Pristup J, Schaeffeler E, Arjune S, Hofmann U, Angel Santamaria-Araujo J, Leuthold P, Friedrich N, Nauck M, Mayr S, Haag M, Muerdter T, Marner FJ, Relling MV, Evans WE, Schwarz G, Schwab M. Pristup J, et al. Among authors: schwab m. Clin Pharmacol Ther. 2022 Oct;112(4):808-816. doi: 10.1002/cpt.2637. Epub 2022 May 31. Clin Pharmacol Ther. 2022. PMID: 35538648 Free PMC article.
1,870 results