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SRSF2 mutation cooperates with ASXL1 truncated alteration to accelerate leukemogenesis.
Sui P, Ge G, Chen S, Bai J, Rubalcava IP, Yang H, Guo Y, Zhang P, Li Y, Medina EA, Xu M, Abdel-Wahab O, Bradley R, Yang FC. Sui P, et al. Among authors: chen s. Leukemia. 2024 Feb;38(2):408-411. doi: 10.1038/s41375-023-02094-6. Epub 2023 Nov 28. Leukemia. 2024. PMID: 38017104 Free PMC article. No abstract available.
ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis.
Guo Y, Zhou Y, Yamatomo S, Yang H, Zhang P, Chen S, Nimer SD, Zhao ZJ, Xu M, Bai J, Yang FC. Guo Y, et al. Among authors: chen s. Leukemia. 2019 May;33(5):1287-1291. doi: 10.1038/s41375-018-0347-y. Epub 2019 Jan 16. Leukemia. 2019. PMID: 30651633 No abstract available.
ASXL1 plays an important role in erythropoiesis.
Shi H, Yamamoto S, Sheng M, Bai J, Zhang P, Chen R, Chen S, Shi L, Abdel-Wahab O, Xu M, Zhou Y, Yang FC. Shi H, et al. Among authors: chen r, chen s. Sci Rep. 2016 Jun 29;6:28789. doi: 10.1038/srep28789. Sci Rep. 2016. PMID: 27352931 Free PMC article.
INTS11 regulates hematopoiesis by promoting PRC2 function.
Zhang P, Sui P, Chen S, Guo Y, Li Y, Ge G, Zhu G, Yang H, Rogers CM, Sung P, Nimer SD, Xu M, Yang FC. Zhang P, et al. Among authors: chen s. Sci Adv. 2021 Sep 3;7(36):eabh1684. doi: 10.1126/sciadv.abh1684. Epub 2021 Sep 1. Sci Adv. 2021. PMID: 34516911 Free PMC article.
Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping.
Yang H, Sui P, Guo Y, Chen S, Maloof ME, Ge G, Nihozeko F, Delma CR, Zhu G, Zhang P, Ye Z, Medina EA, Ayad NG, Mesa R, Nimer SD, Chiang CM, Xu M, Chen Y, Yang FC. Yang H, et al. Among authors: chen s, chen y. EMBO Rep. 2023 Oct 9;24(10):e57032. doi: 10.15252/embr.202357032. Epub 2023 Aug 31. EMBO Rep. 2023. PMID: 37650863 Free article.
Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cell, Leading to Bohring-Opitz-like Syndrome in Mice.
Zhang P, Xing C, Rhodes SD, He Y, Deng K, Li Z, He F, Zhu C, Nguyen L, Zhou Y, Chen S, Mohammad KS, Guise TA, Abdel-Wahab O, Xu M, Wang QF, Yang FC. Zhang P, et al. Among authors: chen s. Stem Cell Reports. 2016 Jun 14;6(6):914-925. doi: 10.1016/j.stemcr.2016.04.013. Epub 2016 May 26. Stem Cell Reports. 2016. PMID: 27237378 Free PMC article.
ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis.
Li Z, Zhang P, Yan A, Guo Z, Ban Y, Li J, Chen S, Yang H, He Y, Li J, Guo Y, Zhang W, Hajiramezanali E, An H, Fajardo D, Harbour JW, Ruan Y, Nimer SD, Yu P, Chen X, Xu M, Yang FC. Li Z, et al. Among authors: chen s, chen x. Sci Adv. 2017 Jan 20;3(1):e1601602. doi: 10.1126/sciadv.1601602. eCollection 2017 Jan. Sci Adv. 2017. PMID: 28116354 Free PMC article.
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